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Article

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

22 Aug 2008

Abstract excerpt

During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic mutation to symptomatic neoplasm, the occurrence of somatic mutations (both driver and passenger) can be used to track the on-going evolution of the neoplasm. All subclones within a cancer are phylogenetically related, with the prevalence of each subclone determined by its evolutionary fitness and the timing of its origin...

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PMID: 18723673
DOI: 10.1073/pnas.0801523105

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