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Article

Bicodon bias can determine the role of synonymous SNPs in human diseases.

BMC genomics - 13 Mar 2017

McCarthy Christina, Carrea Alejandra, Diambra Luis

Abstract excerpt

BACKGROUND: For a long time synonymous single nucleotide polymorphisms were considered as silent mutations. However, nowadays it is well known that they can affect protein conformation and function, leading to altered disease susceptibilities, differential prognosis and/or drug responses, among other clinically relevant genetic traits. This occurs through different mechanisms: by disrupting the splicing signals...

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Identifiers

PMID: 28288557
DOI: 10.1186/s12864-017-3609-6
PMCID: PMC5347174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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