Contribution of intersubunit bridges to the energy barrier of ribosomal translocation.

Abstract excerpt

In every round of translation elongation, EF-G catalyzes translocation, the movement of tRNAs (and paired codons) to their adjacent binding sites in the ribosome. Previous kinetic studies have shown that the rate of tRNA-mRNA movement is limited by a conformational change in the ribosome termed 'unlocking'. Although structural studies offer some clues as to what unlocking might entail, the molecular basis of this...

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