Article
Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator.
Cellular & molecular biology letters - 1 Jan 2016
Bartoszewski Rafal, Króliczewski Jaroslaw, Piotrowski Arkadiusz, Jasiecka Anna Janaszak, Bartoszewska Sylwia, Vecchio-Pagan Briana, Fu Lianwu, Sobolewska Aleksandra, Matalon Sadis, Cutting Garry R, Rowe Steven M, Collawn James F
Abstract excerpt
Synonymous or silent mutations are often overlooked in genetic analyses for disease-causing mutations unless they are directly associated with potential splicing defects. More recent studies, however, indicate that some synonymous single polynucleotide polymorphisms (sSNPs) are associated with changes in protein expression, and in some cases, protein folding and function. The impact of codon usage and mRNA...
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