Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints

16 Jun 2006

Abstract excerpt

BACKGROUND: Gene transfer to synovium in joints has been shown to be an effective approach for treating pathologies associated with rheumatoid arthritis (RA) and related joint disorders. However, the efficiency and duration of gene delivery has been limiting for successful gene therapy for arthritis. The transient gene expression that often accompanies non-viral gene delivery can be prolonged by integration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Rheumatoid Arthritis Research and Therapies
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16779871
DOI: 10.1002/jgm.928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit jointsPMID 16779871Read ↗

Emerging Concepts and Challenges in Rheumatoid Arthritis Gene TherapySemantic proximity Read ↗

Non-viral Gene Therapy for OsteoarthritisSemantic proximity Read ↗

Efficient workflow for validating homology-independent targeted integration-mediated gene insertion in rod photoreceptor cells to treat dominant-negative mutations causing retinitis pigmentosaSemantic proximity Read ↗

Proteasome Inhibition Enhances AAV-Mediated Transgene Expression in Human Synoviocytes in Vitro and in VivoSemantic proximity Read ↗

The TAT Protein Transduction Domain as an Intra-articular Drug-Delivery TechnologySemantic proximity Read ↗

Vector Systems For Gene Transfer to JointsSemantic proximity Read ↗

Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene TransferSemantic proximity Read ↗

Gene therapy as a therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genesSemantic proximity Read ↗

Autoexcision of bacterial artificial chromosome facilitated by terminal repeat-mediated homologous recombination: a novel approach for generating traceless genetic mutants of herpesviruses.Semantic proximity Read ↗

φC31 Integrase-Mediated Nonviral Genetic Correction of Junctional Epidermolysis BullosaSemantic proximity Read ↗

Gene therapy approaches for equine osteoarthritisSemantic proximity Read ↗

Gene therapy for human osteoarthritis: principles and clinical translationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.