Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.

The international journal of biochemistry & cell biology - 1 Jan 2007

Kim Eun-Kyung, Kwon Kang-Beom, Koo Bon-Sun, Han Mi-Jeong, Song Mi-Young, Song Eun-Kyung, Han Myung-Kwan, Park Jin-Woo, Ryu Do-Gon, Park Byung-Hyun

Abstract excerpt

Diabetes mellitus is characterized by cytokine-induced insulitis and a deficit in beta-cell mass. Ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) have been shown to have anti-inflammatory effects in various experimental models. We questioned whether activation of endogenous PPAR-gamma by either PPAR-gamma ligands or adenoviral-directed overexpression of PPAR-gamma (Ad-PPAR-gamma) could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromans
Share to Dinoprostone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to I-kappa B Proteins

Share to Insulin-Secreting Cells

Share to NF-KappaB Inhibitor alpha

Share to Nitrites

Share to Thiazolidinediones

Source

Identifiers

PMID: 17521952
DOI: 10.1016/j.biocel.2007.04.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.PMID 17521952Read ↗

PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells.Semantic proximity Read ↗

PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation.Semantic proximity Read ↗

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta CellsSemantic proximity Read ↗

Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells.Semantic proximity Read ↗

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell lineSemantic proximity Read ↗

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.Semantic proximity Read ↗

Use of Microarray Analysis to Unveil Transcription Factor and Gene Networks Contributing to β Cell Dysfunction and ApoptosisSemantic proximity Read ↗

Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cellsSemantic proximity Read ↗

Endogenous interferon gamma protects against cholestatic liver injury in mice.Semantic proximity Read ↗

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.Semantic proximity Read ↗

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.Semantic proximity Read ↗

The role of NF-κB activation in the pathogenesis of acute pancreatitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.