Article

Delineating JunB’s Crucial Function in Mature Th17 Cells through Inducible Targeted Protein Degradation

2025-01-06

Abstract excerpt

The AP-1 transcription factor JunB is essential for the differentiation of pathogenic T helper 17 (Th17) cells, which are key mediators of autoimmune diseases such as multiple sclerosis and colitis. While the importance of JunB during Th17 polarization is known, its role in mature Th17 cells—critical therapeutic targets in these diseases—remains unclear. In this study, we employed the dTAG system, a targeted prote...

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Literature Corpus work: 26f64dc4-cc39-58e5-9690-bbc3e15bef41
DOI: 10.1101/2025.01.06.631425

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