Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.

doi:10.1172/JCI84645

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Article

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.

The Journal of clinical investigation - 1 Nov 2016

Cantaert Tineke, Schickel Jean-Nicolas, Bannock Jason M, Ng Yen-Shing, Massad Christopher, Delmotte Fabien R, Yamakawa Natsuko, Glauzy Salome, Chamberlain Nicolas, Kinnunen Tuure, Menard Laurence, Lavoie Aubert, Walter Jolan E, Notarangelo Luigi D, Bruneau Julie, Al-Herz Waleed, Kilic Sara Sebnem, Ochs Hans D, Cunningham-Rundles Charlotte, van der Burg Mirjam, Kuijpers Taco W, Kracker Sven, Kaneko Hideo, Sekinaka Yujin, Nonoyama Shigeaki, Durandy Anne, Meffre Eric

Abstract excerpt

Patients with mutations in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral B cell tolerance. AID mediates class-switch recombination (CSR) and somatic hypermutation (SHM) in B cells, but the mechanism by which AID prevents the accumulation of autoreactive B cells in blood is unclear. Here, we analyzed B cell tolerance in AID-deficient patients, patients with...

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Share to AICDA (Activation-Induced Cytidine Deaminase)

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Identifiers

PMID: 27701145
DOI: 10.1172/JCI84645
PMCID: PMC5096912

Genes

AICDA
UNG

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