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Article

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome.

Neurobiology of aging - 1 Jun 2010

Emmanouilidou Evangelia, Stefanis Leonidas, Vekrellis Kostas

Abstract excerpt

Proteasomal dysfunction may play a role in neurodegenerative conditions and protein aggregation. Overexpression in neuronal cells of alpha-synuclein, a molecule linked to Parkinson's Disease, may lead to proteasomal dysfunction. Using PC12 cells stably expressing wild-type or mutant alpha-synuclein and gel filtration, we demonstrate that soluble, intermediate size oligomers of alpha-synuclein co-elute with the...

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PMID: 18715677
DOI: 10.1016/j.neurobiolaging.2008.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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