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Article

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease.

The Journal of cell biology - 5 Mar 2012

Hipp Mark S, Patel Chetan N, Bersuker Kirill, Riley Brigit E, Kaiser Stephen E, Shaler Thomas A, Brandeis Michael, Kopito Ron R

Abstract excerpt

Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington's disease, suggests that highly aggregated proteins interfere with 26S proteasome activity. In this paper, we examine possible mechanisms by which an N-terminal fragment of mutant huntingtin (htt; N-htt) inhibits 26S function. We show that ubiquitinated N-htt-whether aggregated or not-did not choke or...

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Identifiers

PMID: 22371559
DOI: 10.1083/jcb.201110093
PMCID: PMC3307690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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