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Article

Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation.

PLoS medicine - 19 Aug 2008

Rolls Asya, Shechter Ravid, London Anat, Segev Yifat, Jacob-Hirsch Jasmin, Amariglio Ninette, Rechavi Gidon, Schwartz Michal

Abstract excerpt

BACKGROUND: Chondroitin sulfate proteoglycan (CSPG) is a major component of the glial scar. It is considered to be a major obstacle for central nervous system (CNS) recovery after injury, especially in light of its well-known activity in limiting axonal growth. Therefore, its degradation has become a key therapeutic goal in the field of CNS regeneration. Yet, the abundant de novo synthesis of CSPG in response to...

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Identifiers

PMID: 18715114
DOI: 10.1371/journal.pmed.0050171
PMCID: PMC2517615

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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