Article
Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype.
Journal of leukocyte biology - 1 Sept 2008
Ebert Stefanie, Schoeberl Tobias, Walczak Yana, Stoecker Katharina, Stempfl Thomas, Moehle Christoph, Weber Bernhard H F, Langmann Thomas
Abstract excerpt
A disaccharide degradation product of chondrotin sulfate proteoglycan-disaccharide (CSPG-DS) has been implicated previously in the inhibition of neurodegeneration by influencing microglia activation. In this study, genome-wide microarray analysis was used to identify specific gene expression profiles of CSPG-DS-stimulated BV-2 microglia-like cells. Gene products involved in phagocytosis, detoxification,...
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