Article
TP53 codon 72 polymorphism and breast cancer in northern Iran.
Oncology research - 1 Jan 2009
Kazemi Masood, Salehi Zivar, Chakosari Roohi Jamal
Abstract excerpt
The p53 gene is one of the most extensively studied human genes because of its role as a tumor suppressor gene. Its diverse functions include DNA binding, cell cycle control, DNA repair, differentiation, genomic plasticity, and apoptosis. A common polymorphism of the p53 gene at codon 72 has been associated with human cancer susceptibility and prognosis. In this study, we investigated p53 codon 72 polymorphism in...
Topics
- Adult
- Arginine
- Breast Neoplasms
- Codon
- Female
- Gene Frequency
- Genes, p53
- Genotype
- Heterozygote
- Homozygote
- Humans
- Iran
- Middle Aged
