Article
Codon 72 and G13964C intron 6 polymorphisms of TP53 in relation to development and progression of breast cancer in India.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2011
Surekha D, Sailaja K, Rao D Nageswara, Padma T, Raghunadharao D, Vishnupriya S
Abstract excerpt
The p53 protein is at the center of cell regulatory pathways influencing transcription and activity of several replication and transcription factors. In exon 4 of the gene TP53, a codon 72 polymorphism causing an Arg/Pro substitution has been reported in breast and other cancers. This substitution is in the putative SH3 binding domain of p53 protein, influencing binding capacity and thereby functional properties....
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