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Biologic properties and enucleation of red blood cells from human embryonic stem cells

20 Aug 2008

Abstract excerpt

Human erythropoiesis is a complex multistep process that involves the differentiation of early erythroid progenitors to mature erythrocytes. Here we show that it is feasible to differentiate and mature human embryonic stem cells (hESCs) into functional oxygen-carrying erythrocytes on a large scale (10(10)-10(11) cells/6-well plate hESCs). We also show for the first time that the oxygen equilibrium curves of the...

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Identifiers

PMID: 18713948
DOI: 10.1182/blood-2008-05-157198

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