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Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis

28 Aug 2008

Abstract excerpt

A critical issue for clinical utilization of human ES cells (hESCs) is whether they can generate terminally mature progenies with normal function. We recently developed a method for efficient production of hematopoietic progenitors from hESCs by coculture with murine fetal liver-derived stromal cells. Large numbers of hESCs-derived erythroid progenitors generated by the coculture enabled us to analyze the...

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PMID: 18755895
DOI: 10.1073/pnas.0802220105

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