Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Globin switches in yolk sac–like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells

17 Nov 2007

Abstract excerpt

We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immortalized fetal hepatocytes yields CD34(+) cells that can be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac-derived cells. We show here that these primitive erythroblasts undergo a switch in hemoglobin (Hb) composition during late terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Erythrocyte Function and Pathophysiology
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18024790
DOI: 10.1182/blood-2007-07-102087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Globin switches in yolk sac–like primitive and fetal-like definitive red blood cells produced from human embryonic stem cellsPMID 18024790Read ↗

Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globinSemantic proximity Read ↗

Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesisSemantic proximity Read ↗

β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived SacsSemantic proximity Read ↗

A molecular roadmap of definitive erythropoiesis from human induced pluripotent stem cells.Semantic proximity Read ↗

Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co‐express gamma and beta globinsSemantic proximity Read ↗

Self-organized hemanoids derived from human iPSCs create a niche that produces definitive extraembryonic hematopoiesisSemantic proximity Read ↗

Modeling primitive and definitive erythropoiesis with induced pluripotent stem cellsSemantic proximity Read ↗

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryoSemantic proximity Read ↗

Extensive Ex Vivo Expansion of Functional Human Erythroid Precursors Established From Umbilical Cord Blood Cells by Defined FactorsSemantic proximity Read ↗

Erythropoiesis: Model systems, molecular regulators, and developmental programsSemantic proximity Read ↗

Dynamics of human hematopoietic stem and progenitor cell differentiation to the erythroid lineageSemantic proximity Read ↗

Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.