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Article

Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication.

Anesthesia and analgesia - 1 Sept 2008

Stamer Ulrike M, Stüber Frank, Muders Thomas, Musshoff Frank

Abstract excerpt

We observed opioid-related respiratory depression in a patient receiving tramadol via patient-controlled analgesia. Predisposing factors were the patient's genetic background and renal impairment. Complete recovery occurred after naloxone administration, thus confirming opioid intoxication. Analysis of the patient's genotype revealed a CYP2D6 gene duplication resulting in ultra-rapid metabolism of tramadol to its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18713907
DOI: 10.1213/ane.0b013e31817b796e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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