Article
Antiretroviral genotypic resistance in plasma RNA and whole blood DNA in HIV-1 infected patients failing HAART.
Journal of medical virology - 1 Oct 2008
Saracino Annalisa, Gianotti Nicola, Marangi Marianna, Cibelli Donatella C, Galli Andrea, Punzi Grazia, Monno Laura, Lazzarin Adriano, Angarano Gioacchino
Abstract excerpt
The extent to which HIV-1 proviral DNA mutations cause clinically relevant antiretroviral resistance is still controversial. Paired plasma HIV-1 RNA and whole blood DNA were compared in patients failing HAART to investigate if the additional knowledge of archived mutations could improve the selection of potentially active drugs. Seventy-three HIV-1-infected patients with first/second HAART failure were studied...
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