Article
Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy.
Journal of clinical microbiology - 1 Feb 2001
Servais J, Lambert C, Fontaine E, Plesséria J M, Robert I, Arendt V, Staub T, Schneider F, Hemmer R, Burtonboy G, Schmit J C
Abstract excerpt
The resistance of human immunodeficiency virus type 1 (HIV-1) to drugs is a major cause of antiretroviral treatment failure. We have compared direct sequencing to a line probe assay (LiPA) for the detection of drug resistance-related mutations in 197 clinical samples, and we have investigated the...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- Antiretroviral Therapy, Highly Active
- Drug Resistance, Microbial
- Female
- Genotype
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Indinavir