Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development.

Molecular and cellular biology - 1 Oct 2008

Mu Weipeng, Wang Wei, Schimenti John C

Abstract excerpt

Pax transactivation domain-interacting protein (PTIP, or PAXIP1) is required for mouse development and has been implicated in DNA damage responses and histone modification. However, the physiological roles of PTIP during embryogenesis remain unclear due to early embryonic lethality of null mutants. We describe two N-ethyl N-nitrosourea-induced hypomorphic missense alleles of Ptip, each of which alters one of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Cell Movement
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Embryonic Development

Share to Endothelial Cells

Share to Gene Expression Regulation, Developmental

Share to Neovascularization, Physiologic

Source

Open in PubMed Open full text

Identifiers

PMID: 18710940
DOI: 10.1128/MCB.00727-08
PMCID: PMC2577436

Genes

PAXIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development.PMID 18710940Read ↗

BRCT domain-containing protein PTIP is essential for progression through mitosis.Semantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.Semantic proximity Read ↗

Combinatorial function of ETS transcription factors in the developing vasculature.Semantic proximity Read ↗

Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.Semantic proximity Read ↗

Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.Semantic proximity Read ↗

Dosage-dependent requirement for mouse Vezf1 in vascular system development.Semantic proximity Read ↗

Net , an Ets ternary complex transcription factor, is expressed in sites of vasculogenesis, angiogenesis, and chondrogenesis during mouse developmentSemantic proximity Read ↗

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.Semantic proximity Read ↗

Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1.Semantic proximity Read ↗

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryosSemantic proximity Read ↗

Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.