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Article

Potential Contribution of Epithelial Growth Factor Receptor to PI3K/AKT Pathway Dysregulation in Canine Soft Tissue Sarcoma.

In vivo (Athens, Greece) - 1 Jan 2000

Nururrozi Alfarisa, Igase Masaya, Miyanishi Kyohei, Sakurai Masashi, Sakai Yusuke, Tanabe Mika, Mizuno Takuya

Abstract excerpt

BACKGROUND/AIM: Soft tissue sarcoma (STS) is a mesenchymal tumor affecting multiple organs in dogs. Previous studies identified activation of the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (PKB, AKT) pathway in canine STS cell lines and clinical samples, but the underlying mechanism remains unclear. This study investigated PTEN loss, PIK3CA mutation, and EGFR over-expression as potential drivers of...

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PMID: 39740903
DOI: 10.21873/invivo.13808

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Potential Contribution of Epithelial Growth Factor Receptor to PI3K/AKT Pathway Dysregulation in Canine Soft Tissue Sarcoma.PMID 39740903Read ↗

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