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Article

Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma.

PloS one - 1 Jan 2014

Both Joeri, Krijgsman Oscar, Bras Johannes, Schaap Gerard R, Baas Frank, Ylstra Bauke, Hulsebos Theo J M

Abstract excerpt

Osteosarcoma is an aggressive bone tumor that preferentially develops in adolescents. The tumor is characterized by an abundance of genomic aberrations, which hampers the identification of the driver genes involved in osteosarcoma tumorigenesis. Our study aims to identify these genes by the investigation of focal copy number aberrations (CNAs, <3 Mb). For this purpose, we subjected 26 primary tumors of...

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Source

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Identifiers

PMID: 25551557
DOI: 10.1371/journal.pone.0115835
PMCID: PMC4281204

Genes

CMTM8
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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