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Article

Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.

Cancer research - 15 Mar 2009

Sheu Jim Jinn-Chyuan, Hua Chun-Hung, Wan Lei, Lin Ying-Ju, Lai Ming-Tsung, Tseng Hsien-Chang, Jinawath Natini, Tsai Ming-Hsui, Chang Nai-Wen, Lin Chin-Fen, Lin Chyi-Chyang, Hsieh Lie-Jiau, Wang Tian-Li, Shih Ie-Ming, Tsai Fuu-Jen

Abstract excerpt

A 250K single-nucleotide polymorphism array was used to study subchromosomal alterations in oral squamous cell carcinoma (OSCC). The most frequent amplification was found at 7p11.2 in 9 of 29 (31%) oral cancer patients. Minimal genomic mapping verified a unique amplicon spanning from 54.6 to 55.3 Mb on chromosome 7, which contains SEC61G and epidermal growth factor receptor (EGFR). Results from fluorescence in...

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Source

Identifiers

PMID: 19276369
DOI: 10.1158/0008-5472.CAN-08-3199

Genes

EGFR
CCND1
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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