Article
A comprehensive resequence-analysis of 250 kb region of 8q24.21 in men of African ancestry.
The Prostate - 1 May 2014
Chung Charles C, Hsing Ann W, Edward Yeboah, Biritwum Richard, Tettey Yao, Adjei Andrew, Cook Michael B, De Marzo Angelo, Netto George, Tay Evelyn, Boland Joseph F, Yeager Meredith, Chanock Stephen J
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified that a ∼1 M region centromeric to the MYC oncogene on chromosome 8q24.21 harbors at least five independent loci associated with prostate cancer risk and additional loci associated with cancers of breast, colon, bladder, and chronic lymphocytic leukemia (CLL). Because GWAS identify genetic markers that may be indirectly associated with disease,...
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