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The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

14 Aug 2008

Abstract excerpt

There is an interesting overlap of function in a wide range of organisms between genes that modulate the stress responses and those that regulate aging phenotypes and, in some cases, lifespan. We have therefore screened mutagenized zebrafish embryos for the altered expression of a stress biomarker, senescence-associated beta-galactosidase (SA-beta-gal) in our current study. We validated the use of embryonic...

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PMID: 18704191
DOI: 10.1371/journal.pgen.1000152

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