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Mutual suppression between mutations in the Dictyostelium Greenbeard pathway restores wild-type development.

BMC genomics - 5 Jun 2025

Katoh-Kurasawa Mariko, Trnovec Lena, Lehmann Peter, Zupan Blaž, Shaulsky Gad

Abstract excerpt

BACKGROUND: The Dictyostelium greenbeard pathway is mediated by two polymorphic transmembrane proteins, the TgrC1 ligand and the TgrB1 receptor. These proteins mediate allorecognition, altruism, and the developmental transition to multicellularity. A genetic suppressor screen revealed activating mutations in tgrB1 and inactivating mutations in rapgapB, a regulator of the GTPase protein RapA. Inactivation of...

Topics

Dictyostelium
Mutation
Protozoan Proteins
Signal Transduction
GTPase-Activating Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40474076
DOI: 10.1186/s12864-025-11745-0
PMCID: PMC12142906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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