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Article

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Neuron - 5 Feb 2014

Alami Nael H, Smith Rebecca B, Carrasco Monica A, Williams Luis A, Winborn Christina S, Han Steve S W, Kiskinis Evangelos, Winborn Brett, Freibaum Brian D, Kanagaraj Anderson, Clare Alison J, Badders Nisha M, Bilican Bilada, Chaum Edward, Chandran Siddharthan, Shaw Christopher E, Eggan Kevin C, Maniatis Tom, Taylor J Paul

Abstract excerpt

The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral sclerosis and some types of frontotemporal lobar degeneration. The importance of TDP-43 in disease is underscored by the fact that dominant missense mutations are sufficient to cause...

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Identifiers

PMID: 24507191
DOI: 10.1016/j.neuron.2013.12.018
PMCID: PMC3939050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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