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Article

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.

Human molecular genetics - 15 Aug 2012

Fallini Claudia, Bassell Gary J, Rossoll Wilfried

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease specifically affecting cortical and spinal motor neurons. Cytoplasmic inclusions containing hyperphosphorylated and ubiquitinated TDP-43 are a pathological hallmark of ALS, and mutations in the gene encoding TDP-43 have been directly linked to the development of the disease. TDP-43 is a ubiquitous DNA/RNA-binding protein with a nuclear role in...

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Identifiers

PMID: 22641816
DOI: 10.1093/hmg/dds205
PMCID: PMC3406762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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