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Article

Connecting TDP-43 Pathology with Neuropathy.

Trends in neurosciences - 1 Jun 2021

Klim Joseph R, Pintacuda Greta, Nash Leslie A, Guerra San Juan Irune, Eggan Kevin

Abstract excerpt

Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-binding protein, is a primary component of insoluble aggregates associated with several devastating nervous system disorders; mutations in TARDBP, its encoding gene, are a cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we review established and emerging roles of TDP-43 and...

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Identifiers

PMID: 33832769
DOI: 10.1016/j.tins.2021.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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