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Article

TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA.

FEBS letters - 8 Jul 2015

Che Mei-Xia, Jiang Lei-Lei, Li Hai-Yin, Jiang Ya-Jun, Hu Hong-Yu

Abstract excerpt

TDP-43 (TAR DNA binding protein of 43 kDa) and its C-terminal fragments are thought to be linked to the pathologies of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Here, we demonstrate that the aggregates or inclusions formed by its 35-kDa fragment (namely TDP-35) sequeste...

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Identifiers

PMID: 26099433
DOI: 10.1016/j.febslet.2015.06.009

Genes

RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26099433-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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