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Article

Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers.

Biochemical pharmacology - 1 Oct 2008

Muscat Joshua E, Pittman Brian, Kleinman Wayne, Lazarus Philip, Stellman Steven D, Richie John P

Abstract excerpt

The lower incidence rate of transitional cell carcinoma of the urinary bladder in blacks than in whites may be due to racial differences in the catalytic activity of enzymes that metabolize carcinogenic arylamines in tobacco smoke. To examine this, we compared cytochrome P4501A2 (CYP1A2) and N-acetyltransferase-2 activities (NAT2) in black and white smokers using urinary caffeine metabolites as a probe for enzyme...

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Source

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Identifiers

PMID: 18703023
DOI: 10.1016/j.bcp.2008.07.024
PMCID: PMC2597011

Genes

NAT2
GSTM1
GSTM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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