Article
Combined effect of smoking and inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 on bladder cancer in a Tunisian population.
Cancer genetics and cytogenetics - 15 Apr 2009
Rouissi Kamel, Ouerhani Slah, Marrakchi Raja, Ben Slama Mohamed R, Sfaxi Mohamed, Ayed Mohsen, Chebil Mohamed, El Gaaied Amel Benammar
Abstract excerpt
Cigarette smoking is the predominant risk factor for bladder cancer in males and females. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes, such as the super-families of N-acetyltransferases (NAT) and glutathione S-transferases (GST). Polymorphisms in NAT and GST genes alter the ability of these enzymes to metabolize carcinogens. We have conducted this case-control study to...
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