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Article

Smoking and polymorphisms in xenobiotic metabolism and DNA repair genes are additive risk factors affecting bladder cancer in Northern Tunisia.

Pathology oncology research : POR - 1 Dec 2011

Rouissi Kamel, Ouerhani Slah, Hamrita Bechr, Bougatef Karim, Marrakchi Raja, Cherif Mohamed, Ben Slama Mohamed Riadh, Bouzouita Mohamed, Chebil Mohamed, Ben Ammar Elgaaied Amel

Abstract excerpt

Cancer epidemiology has undergone marked development since the nineteen-fifties. One of the most spectacular and specific contributions was the demonstration of the massive effect of smoking and genetic polymorphisms on the occurrence of bladder cancer. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes, such as the super-families of N-acetyltransferases (NAT) and glutathione...

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Source

Identifiers

PMID: 21647780
DOI: 10.1007/s12253-011-9398-3

Genes

NAT2
GSTM1
GSTT1
XPC

Provenance

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Smoking and polymorphisms in xenobiotic metabolism and DNA repair genes are additive risk factors affecting bladder cancer in Northern Tunisia.PMID 21647780Read ↗

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