Article
Calnexin is involved in apoptosis induced by endoplasmic reticulum stress in the fission yeast.
Molecular biology of the cell - 1 Oct 2008
Guérin Renée, Arseneault Geneviève, Dumont Stéphane, Rokeach Luis A
Abstract excerpt
Stress conditions affecting the functions of the endoplasmic reticulum (ER) cause the accumulation of unfolded proteins. ER stress is counteracted by the unfolded-protein response (UPR). However, under prolonged stress the UPR initiates a proapoptotic response. Mounting evidence indicate that the ER chaperone calnexin is involved in apoptosis caused by ER stress. Here, we report that overexpression of calnexin in...
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