Article
The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.
Journal of cell science - 1 Jun 2009
Abu-Hamad Salah, Arbel Nir, Calo Doron, Arzoine Laetitia, Israelson Adrian, Keinan Nurit, Ben-Romano Ronit, Friedman Orr, Shoshan-Barmatz Varda
Abstract excerpt
The release of mitochondrial-intermembrane-space pro-apoptotic proteins, such as cytochrome c, is a key step in initiating apoptosis. Our study addresses two major questions in apoptosis: how are mitochondrial pro-apoptotic proteins released and how is this process regulated? Accumulating evidence indicates that the voltage-dependent anion channel (VDAC) plays a central role in mitochondria-mediated apoptosis....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.