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Article

Defects in N-glycosylation induce apoptosis in yeast.

Molecular microbiology - 1 Feb 2006

Hauptmann Peter, Riel Constanze, Kunz-Schughart Leoni A, Fröhlich Kai-Uwe, Madeo Frank, Lehle Ludwig

Abstract excerpt

N-glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N-glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid-linked core-oligosaccharide to the nascent polypeptide chain, catalysed by the oligosaccharyltransferase. One of its nine...

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Source

Identifiers

PMID: 16420350
DOI: 10.1111/j.1365-2958.2005.04981.x

Genes

DAD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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