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Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer

1 May 2017

Abstract excerpt

Golgi anti-apoptotic protein (GAAP), also known as transmembrane Bax inhibitor-1 motif-containing 4 (TMBIM4) or Lifeguard 4 (Lfg4), shares remarkable amino acid conservation with orthologues throughout eukaryotes, prokaryotes and some orthopoxviruses, suggesting a highly conserved function. GAAPs regulate Ca2+levels and fluxes from the Golgi and endoplasmic reticulum, confer resistance to a broad range of...

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PMID: 28469007
DOI: 10.1098/rsob.170045

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