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The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells

3 Dec 2011

Abstract excerpt

JMJD2A is a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysines 9 and 36 and is overexpressed in human tumors, but its role in oncogenesis remains unclear. Here, we show that JMJD2A interacts with the tumor suppressor p53 both in vitro and in HCT116 colon cancer cells. Chromatin immunoprecipitation assays demonstrated that JMJD2A was recruited together with p53 to the promoter...

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PMID: 22134899
DOI: 10.1002/jcb.24009

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