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Article

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.

Nature communications - 23 Dec 2016

Chao Tengfei, Zhou Xiang, Cao Bo, Liao Peng, Liu Hongbing, Chen Yun, Park Hee-Won, Zeng Shelya X, Lu Hua

Abstract excerpt

The tumour suppressor p53 transactivates the expression of its target genes to exert its functions. Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-encoding gene as a p53 target. PHLDB3 overexpression increases proliferation and restrains apoptosis of wild-type p53-harboring cancer cells by reducing p53 protein levels. PHLDB3 binds to MDM2 (mouse double minute 2 homolog) and facilitates...

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Source

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Identifiers

PMID: 28008906
DOI: 10.1038/ncomms13755
PMCID: PMC5196188

Genes

PHLDB3
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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