Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity.

Archives of biochemistry and biophysics - 1 Feb 2012

Vaughan Catherine A, Singh Shilpa, Windle Brad, Sankala Heidi M, Graves Paul R, Andrew Yeudall W, Deb Swati P, Deb Sumitra

Abstract excerpt

Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-type p53 and show "gain of function" (GOF) phenotypes such as increased growth rate, enhanced resistance to chemotherapeutic drugs, increased cell motility and tumorigenicity; although the mechanism for this function remains unknown. In this communication we report that p53-mediated NF-κB2 up-regulation significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to CREB-Binding Protein

Share to Histones

Share to RNA Interference

Share to STAT Transcription Factors

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 22198284
DOI: 10.1016/j.abb.2011.12.006
PMCID: PMC3272778

Genes

STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity.PMID 22198284Read ↗

Tumor-derived p53 mutants induce NF-kappaB2 gene expression.Semantic proximity Read ↗

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration.Semantic proximity Read ↗

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.Semantic proximity Read ↗

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling.Semantic proximity Read ↗

TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.Semantic proximity Read ↗

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.Semantic proximity Read ↗

Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase AxlSemantic proximity Read ↗

Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific TransactivatorsSemantic proximity Read ↗

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells.Semantic proximity Read ↗

Mutant p53 gain of function: the NF-Y connection.Semantic proximity Read ↗

Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function.Semantic proximity Read ↗

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.