The transmembrane topology of the amino terminus of the alpha subunit of the nicotinic acetylcholine receptor.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The transmembrane topology of the amino terminus of the alpha subunit of the nicotinic acetylcholine receptor.

The Journal of biological chemistry - 15 Aug 1991

Chavez R A, Hall Z W

Abstract excerpt

We have investigated the transmembrane topology of the amino-terminal domain of the alpha subunit of the mouse muscle nicotinic acetylcholine receptor synthesized in vitro and in vivo. Using oligonucleotide-directed mutagenesis we introduced new glycosylation consensus sequences at alpha 154 and at alpha 200. For each novel site, additional constructs were made in which the original site at alpha N141 was...

Topics

Acetylcholine
Amino Acid Sequence
Animals
Base Sequence
Cell Line
DNA
Dogs
Glycosylation
Mice
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precipitin Tests

Protein Biosynthesis

Protein Conformation

Rabbits

Receptors, Nicotinic

Torpedo

Source

Open in PubMed

Identifiers

PMID: 1869570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1869570-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transmembrane topology of the amino terminus of the alpha subunit of the nicotinic acetylcholine receptor.PMID 1869570Read ↗

Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors.Semantic proximity Read ↗

An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors.Semantic proximity Read ↗

Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors.Semantic proximity Read ↗

Cell-free expression and functional reconstitution of homo-oligomeric alpha7 nicotinic acetylcholine receptors into planar lipid bilayers.Semantic proximity Read ↗

Soluble, oligomeric, and ligand-binding extracellular domain of the human alpha7 acetylcholine receptor expressed in yeast: replacement of the hydrophobic cysteine loop by the hydrophilic loop of the ACh-binding protein enhances protein solubility.Semantic proximity Read ↗

A small cytoplasmic region adjacent to the fourth transmembrane segment of the α7 nicotinic receptor is essential for its biogenesis.Semantic proximity Read ↗

Molecular determinants conferring alpha-toxin resistance in recombinant DNA-derived acetylcholine receptors.Semantic proximity Read ↗

Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.Semantic proximity Read ↗

Contributions of N-linked glycosylation to the expression of a functional alpha7-nicotinic receptor in Xenopus oocytes.Semantic proximity Read ↗

Expression of Soluble Ligand- and Antibody-binding Extracellular Domain of Human Muscle Acetylcholine Receptor α Subunit in Yeast Pichia pastorisSemantic proximity Read ↗

Transmembrane topology and oligomeric structure of the high-affinity choline transporter.Semantic proximity Read ↗

Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.