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Article

Molecular determinants conferring alpha-toxin resistance in recombinant DNA-derived acetylcholine receptors.

The Journal of biological chemistry - 24 Feb 1995

Keller S H, Kreienkamp H J, Kawanishi C, Taylor P

Abstract excerpt

Sequences of the alpha-subunits of the nicotinic acetylcholine receptor from the snake and mongoose contain several differences in the region between amino acids 183 and 200. Receptors from both of these species reveal resistance to the snake alpha-toxins presumably arising as a protective evolutionary mechanism. Sequence differences include the added glycosylation signals at residue 187 in the mongoose and at...

Topics

Amino Acid Sequence
Animals
Bungarotoxins
Cells, Cultured
DNA, Recombinant
Drug Resistance
Glycosylation
Humans
Molecular Sequence Data
Mutation
Receptors, Nicotinic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Type C Phospholipases

Source

Identifiers

PMID: 7876169
DOI: 10.1074/jbc.270.8.4165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7876169-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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