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Article

Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants.

The journal of physical chemistry. B - 4 Sept 2008

Grabenauer Megan, Bernstein Summer L, Lee Jennifer C, Wyttenbach Thomas, Dupuis Nicholas F, Gray Harry B, Winkler Jay R, Bowers Michael T

Abstract excerpt

Aggregation of alpha-synuclein (alpha-syn), a protein implicated in Parkinson's disease (PD), is believed to progress through formation of a partially folded intermediate. Using nanoelectrospray ionization (nano-ESI) mass spectrometry combined with ion mobility measurements we found evidence for a highly compact partially folded family of structures for alpha-syn and its disease-related A53T mutant with net...

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Identifiers

PMID: 18693700
DOI: 10.1021/jp801175w
PMCID: PMC2639767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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