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Article

Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652.

European journal of pharmacology - 25 Mar 2010

Xing Junlian, Ma Jihua, Zhang Peihua, Fan Xinrong

Abstract excerpt

The objectives of this study were to investigate the inhibitory action of capsaicin on wild-type (WT) and mutation human ether-a-go-go-related gene (hERG) potassium channel currents (I(hERG)), and to determine whether mutations in the S6 region are significant for the inhibition of I(hERG) by capsaicin. The hERG channel (WT, Y652A and F656A) was expressed in Xenopus oocytes and studied using standard...

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Identifiers

PMID: 19903464
DOI: 10.1016/j.ejphar.2009.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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