Polymorphisms in the LOC387715/ARMS2 putative gene and the risk for Alzheimer's disease.

doi:10.1159/000151050

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Article

Polymorphisms in the LOC387715/ARMS2 putative gene and the risk for Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Gatta Luisa Benerini, Vitali Massimiliano, Zanola Alessandra, Venturelli Eliana, Fenoglio Chiara, Galimberti Daniela, Scarpini Elio, Finazzi Dario

Abstract excerpt

BACKGROUND: Age-related macular degeneration (ARMD) and Alzheimer's disease (AD) are neurodegenerative disorders that share a high prevalence among elderly people, the extracellular deposition of beta-amyloid and the involvement of genetic factors in their aetiology. Genetic linkage with the chromosome regions 10q26 and 10q24-25 have been shown for ARMD and AD, respectively. The rs10490924 polymorphism, the major...

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Identifiers

PMID: 18688167
DOI: 10.1159/000151050

Genes

ARMS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Polymorphisms in the LOC387715/ARMS2 putative gene and the risk for Alzheimer's disease.PMID 18688167Read ↗

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Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7.Semantic proximity Read ↗

Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

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