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Article

Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.

Neurobiology of aging - 1 Mar 2011

Bekris L M, Galloway N M, Millard S, Lockhart D, Li G, Galasko D R, Farlow M R, Clark C M, Quinn J F, Kaye J A, Schellenberg G D, Leverenz J B, Seubert P, Tsuang D W, Peskind E R, Yu C E

Abstract excerpt

The aim of this exploratory investigation was to determine if genetic variation within amyloid precursor protein (APP) or its processing enzymes correlates with APP cleavage product levels: APPα, APPβ or Aβ42, in cerebrospinal fluid (CSF) of cognitively normal subjects or Alzheimer's disease (AD) patients. Cognitively normal control subjects (n = 170) and AD patients (n = 92) were genotyped for 19 putative...

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Source

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Identifiers

PMID: 21196064
DOI: 10.1016/j.neurobiolaging.2010.10.020
PMCID: PMC3065534

Genes

APP
ADAM10
APOE
BACE1
BACE2
NCSTN
PSEN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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