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Article

Soluble forms of the Notch ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes.

The American journal of pathology - 1 Sept 2008

Urs Sumithra, Roudabush Alice, O'Neill Christine F, Pinz Ilka, Prudovsky Igor, Kacer Doreen, Tang Yuefang, Liaw Lucy, Small Deena

Abstract excerpt

We previously found that soluble forms of the Notch ligands Jagged1 and Delta1 induced fibroblast growth factor receptor-dependent cell transformation in NIH3T3 fibroblasts. However, the phenotypes of these lines differed, indicating distinct functional differences among these Notch ligands. In the present study, we used allografts to test the hypothesis that NIH3T3 fibroblasts that express soluble forms of...

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Identifiers

PMID: 18688026
DOI: 10.2353/ajpath.2008.080006
PMCID: PMC2527077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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