Article
Transformed phenotype conferred to NIH/3T3 cells by ectopic expression of heparin-binding growth factor 1/acidic fibroblast growth factor.
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 Jan 1991
Bunnag P, Waddell K S, Varban M L, Chiu I M
Abstract excerpt
Heparin-binding growth factor 1 (HBGF-1), also known as acidic fibroblast growth factor, is a potent mitogen and angiogenic factor found in tissues such as brain, kidney and heart. The genomic and cDNA sequences indicate that HBGF-1 does not have a typical signal peptide sequence. HBGF-1 was shown to be localized to the extracellular matrix of cardiac myocytes, but the mechanism of secretion is not presently...
Topics
- Animals
- Cell Adhesion
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cloning, Molecular
- DNA Replication
- Fibroblast Growth Factor 1
- Mice
- Phenotype
- Plasmids