Article
Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis.
Current medical research and opinion - 1 Sept 2008
Marini Francesca, Falchetti Alberto, Silvestri Sandra, Bagger Yu, Luzi Ettore, Tanini Annalisa, Christiansen Claus, Brandi Maria Luisa
Abstract excerpt
INTRODUCTION: Polymorphisms of genes encoding enzymes of the mevalonate pathway could modulate the response to amino-bisphosphonate treatment in postmenopausal osteoporosis. RESEARCH DESIGN AND METHODS: A characterisation of 234 Danish osteoporotic postmenopausal women (as part of the Prospective Epidemiological Risk Factors study (PERF)), treated for at least 2 years with amino-bisphosphonates, with respect to...
Topics
- Aged
- Bone Density
- Bone Density Conservation Agents
- Bone Remodeling
- Diphosphonates
- Female
- Genotype
- Geranyltranstransferase
- Humans
- Middle Aged
- Polymorphism, Genetic
- Postmenopause